Perhaps remove the bone beads, or end them once the cinnabar begins?

I agree with lindabd. The bone beads seem to take the focus off the cloisonné beads. I suggest using the blue beads only as spacers.

These suggestions would need to be mocked up to see if they look good: 1)You could eliminate the pair (or two pairs) of cinnabar beads closest to the clasp to make the necklace a little shorter or, 2) instead of alternating cloisonné and cinnabar beads, you could start with three cloisonné beads at the center, flanked by cinnabar beads--one on each side--and then two cloisonné beads on each side. W/ suggestion no. 2, use fewer cinnabar beads to make it shorter.

I used to use bone spacers, but no longer. I decided light colored spacers dominate too much, especially when used with jewel tones or dark colors. They also add too much length. If you could find cinnabar in graduated sizes, that would look rad. Maximize color, use white sparingly. Put fat knots between the beads. Remember to put some small beads next to the clasp to make room for fingers.

put little 6mm brass disc in-between beads in between. I like these and need to get more - and they come in a bigger hole size, good for leather...

Try to pick up the color of the cloisonne wire work.

Antiqued brass generally adds an "antique period look" IMHO. Several examples -

The way I learned it is: "If it is busy, make it busier." But, I have tried unsuccessfully every time; I don't think it is possible to enriched the look of cloisonné beads. Even beautiful Japanese Meiji Era cloisonné beads are extremely difficult.

So, I decided to use the least possible in between…maybe just a matte black Japanese seed bead? A small round bead in the right size would allow the cloisonné beads to swivel and would protect the enamel from abrasion.

And large numbers of these necklaces appear to have been sold. Most of them have remained intact -coming up again and again in the antiques markets- with appropriate attribution to Mariam Haskell. It would be difficult to reassemble one of these with an authentic appearance because patina on the brass would vary too much. And the brass components Mariam Haskell used are distinctive.

Wondering if the chain was originally designed as a pocket watch chain ?