The earliest millefiori that we know is #360 on the Venetian bead book in the British museum (circa 1850/1865). Here is a not very good picture of it.
It is scattered with slices of blue and green rosetta cane over a trail decorated bead.
We have a very similar bead on the cover of our millefiori book as #29.
So far we have not seen others, but it might come someday.
JP